Shuichi Hirai Selected Research

Orchitis

3/2022	GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis.
9/2015	Low-dose exposure to di-(2-ethylhexyl) phthalate (DEHP) increases susceptibility to testicular autoimmunity in mice.
9/2014	Neonatal exposure to diethylstilbestrol causes granulomatous orchitis via epididymal inflammation.
12/2013	Serum autoantibodies in mice immunized with syngeneic testicular germ cells alone.
7/2013	Cadmium exposure increases susceptibility to testicular autoimmunity in mice.
12/2012	Postinflammation stage of autoimmune orchitis induced by immunization with syngeneic testicular germ cells alone in mice.
12/2012	Experimental autoimmune orchitis as a model of immunological male infertility.
8/2011	Experimental model of autoimmune orchitis with abdominal placement of donor's testes, epididymides, and vasa deferentia in recipient mice.
4/2011	Intratesticular expression of mRNAs of both interferon γ and tumor necrosis factor α is significantly increased in experimental autoimmune orchitis in mice.
12/2010	Developmental ontogeny of autoantigens associated with localized autoimmunity in murine testis and epididymis.

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Shuichi Hirai Research Topics

Disease

12	Orchitis 03/2022 - 06/2008
8	Inflammation (Inflammations) 12/2014 - 06/2008
4	Infertility (Sterility) 10/2016 - 09/2010
3	Brain Injuries (Brain Injury) 01/2021 - 01/2016
3	Neoplasms (Cancer) 12/2019 - 08/2013
3	Heart Arrest (Cardiac Arrest) 01/2019 - 09/2015
3	Body Weight (Weight, Body) 01/2014 - 01/2010
2	Infections 01/2022 - 01/2016
2	Wounds and Injuries (Trauma) 01/2021 - 07/2009
2	Azoospermia 12/2019 - 03/2014
2	Epididymitis 12/2010 - 06/2008
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Pain (Aches) 01/2021
1	Proteinuria 01/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Knee Osteoarthritis 01/2021
1	Albuminuria 01/2021
1	Pre-Eclampsia (Preeclampsia) 01/2021
1	Lung Neoplasms (Lung Cancer) 06/2020
1	Spinal Cord Ischemia 01/2019
1	Paraplegia (Spastic Paraplegia) 01/2019
1	Heart Failure 10/2015
1	Hypertrophy 10/2015
1	Acute Liver Failure (Fulminant Hepatic Failure) 12/2014
1	Pancreatic Neoplasms (Pancreatic Cancer) 08/2013
1	Cicatrix (Scar) 08/2013
1	Necrosis 07/2013
1	Male Infertility (Male Sterility) 08/2011
1	Obesity 01/2010
1	Pancreatitis 01/2010
1	Chronic Pancreatitis 01/2010
1	Hypersensitivity (Allergy) 07/2009
1	Rupture 07/2009

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2013
4	AntigensIBA 09/2015 - 12/2010
3	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2021 - 09/2015
3	Messenger RNA (mRNA)IBA 01/2021 - 06/2008
3	AutoantibodiesIBA 09/2015 - 08/2011
1	Differentiation AntigensIBA 03/2022
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2022
1	CarbohydratesIBA 01/2022
1	Hyaluronic Acid (Hyaluronan)IBA 01/2021
1	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 01/2021
1	Iodoacetic AcidIBA 01/2021
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021
1	Hyaluronan ReceptorsIBA 01/2021
1	Sulfides (Thioethers)IBA 01/2021
1	Methotrexate (Mexate)FDA LinkGeneric 01/2021
1	Biotin (Vitamin H)FDA Link 01/2021
1	sulfide quinone reductaseIBA 01/2021
1	Oxygen (Dioxygen)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 06/2020
1	glutathione-independent formaldehyde dehydrogenase (formaldehyde dehydrogenase)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2016
1	Pyruvic Acid (Pyruvate)IBA 01/2016
1	SaltsIBA 01/2016
1	Neuroprotective AgentsIBA 01/2016
1	Thiamine (Aneurin)FDA Link 01/2016
1	SolutionsIBA 01/2016
1	Protein SIBA 10/2015
1	CalciumIBA 10/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2015
1	Adrenergic Receptors (Adrenergic Receptor)IBA 10/2015
1	Adrenergic Agents (Adrenergic Drugs)IBA 10/2015
1	LipidsIBA 12/2014
1	tipifarnib (R115777)IBA 12/2014
1	Farnesyltranstransferase (Farnesyltransferase)IBA 12/2014
1	LipopolysaccharidesIBA 12/2014
1	GalactosamineIBA 12/2014
1	Cysteine (L-Cysteine)FDA Link 12/2014
1	Diethylstilbestrol (Stilbestrol)FDA Link 09/2014
1	Estradiol (Delestrogen)FDA LinkGeneric 03/2014
1	Estrogens (Estrogen)FDA Link 03/2014
1	LuciferasesIBA 08/2013
1	Adenosine Diphosphate (ADP)IBA 08/2013
1	CadmiumIBA 07/2013
1	Cadmium Chloride (Cadmium Dichloride)IBA 07/2013
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 09/2012
1	Freund's AdjuvantIBA 08/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2011
1	InterferonsIBA 04/2011
1	CortactinIBA 09/2010
1	Contraceptive Agents (Contraceptives)IBA 09/2010
1	Tyrosine (L-Tyrosine)FDA Link 09/2010
1	Protein Isoforms (Isoforms)IBA 09/2010
1	GhrelinIBA 01/2010
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/2009
1	AutoantigensIBA 06/2008
1	VX (EDIM)IBA 06/2008

Therapy/Procedure

5	Subcutaneous Injections 01/2014 - 09/2008
3	Cardiopulmonary Resuscitation (CPR) 01/2019 - 09/2015
2	Therapeutics 12/2019 - 10/2016
2	Drug Therapy (Chemotherapy) 12/2019 - 08/2013
1	Transplantation 01/2022
1	Intraperitoneal Injections 01/2021
1	Radiotherapy 12/2019
1	Resuscitation 01/2019
1	Splenectomy 01/2010